PCHPI Annual Scientific Meeting

Each year, the PCHPI holds a meeting to promote the center and to establish dialogue with prominent HIV researchers from across the country. A synopsis of our past meetings is below.

First Annual meeting of the Pittsburgh Center for HIV Protein Interactions – April 11, 2008

The primary goal of our inaugural meeting was to raise awareness of our relatively new center and of our two sister centers. We invited researchers from several different institutions to give talks on their areas of interest. These were followed by discussions and a tour of our center’s facilities. Speakers included: Irvin Chen, Director, UCLA AIDS Institute, University of California, Los Angeles; John D. Gross, University of California, San Francisco; Thomas Hope, Northwestern University Medical School;James A. Hoxie, Director, Penn Center for AIDS Research, University of Pennsylvania; Alak K. Kar, Dana-Farber Cancer Institute, Center for Immunology and AIDS; Julie A.E. Nelson, Center for AIDS Research, University of North Carolina at Chapel Hill; and Mario Stevenson, Director, Center for AIDS Research, University of Massachusetts Medical School.

Second Annual meeting of the Pittsburgh Center for HIV Protein Interactions – May 13, 2009

The focus of our second meeting was early events in retroviral cellular infection, including retroviral restriction and HIV nuclear entry. In the second year, we incorporated a poster session to highlight the work being conducted at our center. Speakers included a future collaborator, a PCHPI member, and experts in retroviral restriction. Jacek Skowronski, Cold Spring Harbor Laboratory, spoke about Vpr and Vpx deregulation of Cullin 4-based E3 ubiquitin ligase; Vineet Kewal-Ramani, Chief, Model Development Section, HIV Drug Resistance Program, NCI, spoke about the regulation of HIV-1 nuclear entry, and Peijun Zhang, University of Pittsburgh School of Medicine, PCHPI member, presented an integrated view of the HIV-1 Capsid with a focus on CryoEM, X-ray and NMR data generated in our center. Stephen Goff of the Howard Hughes Medical Institute and Columbia University College of Physicians and Surgeons discussed restriction of retrovirus replication by ZAP and ZFP809, followed by Klaus Strebel, Chief, Viral Biochemistry Section Laboratory of Molecular Microbiology, NIAID, who presented an update on restriction of HIV-1 replication by APOBEC3G.

Third Annual Meeting of the Pittsburgh Center for HIV Protein Interactions – May 19, 2010

At the 2010 meeting, we had a primary focus on accessory proteins and restriction. Felipe Diaz-Griffero presented structure-function studies on the HIV-1 restriction factor TRIM5α; Nathaniel Landau discussed the role of the Vpr and Vpx accessory proteins in overcoming a post-entry block to virus replication; Joanne Yeh presented the X-ray structures of HIV Vpr in complex with DCAF1 CRL4 ubiquitin ligase, Paul Bieniasz presented a talk entitled: Tethering Virions—Battles at the Cell Surface Between Enveloped Viruses and Their Hosts, and Nevan Krogan discussed his approach to obtain functional insights into HIV-1 from protein-protein and genetic interaction maps.

Fourth Annual Meeting of the Pittsburgh Center for HIV Protein Interactions –April 21, 2011

The 2011 meeting included seminars by experts on HIV-1 assembly, integration, and interactions with cellular components. Dr.Eric Freed, Head of the Virus-Cell Interaction Section of the HIV Drug Resistance Program at the National Cancer Institute, spoke about HIV-1 assembly, release, and maturation, and Dr. Peter Prevelige,Professor of Microbiology at the University of Alabama @ Birmingham presented his mass spectrometry based studies of HIV assembly and maturation.  Dr. Alan Engelman, Associate Professor of Medicine, Department of Cancer Immunology and AIDS at the Dana-Farber Cancer Institute, discussed Control over HIV-1 integration, and Dr. Wah Chiu, Distinguished Service Professor of Biochemistry & Molecular Biology at the Baylor College of Medicine, presented his studies aimed at seeing structural morphogenesis of dsDNA viruses from assembly to infection.  Dr. Jinwoo Ahn presented studies from our center, on the structure and biochemistry of HIV-1 Vpr interaction with CRL4 E3 ubiquitin ligase components.

Fifth Annual Meeting of the Pittsburgh Center for HIV Protein Interactions - May 9, 2012

The focus of our fifth meeting was innate immune factors as they relate to HIV-1 pathogenesis.  Several internationally recognized investigators in this area of research gave talks: Michael Emerman from the Fred Hutchinson Cancer Research Center spoke on the Evolution and Function of Restriction Factors Against HIV and Related Viruses, focusing on the restriction factors tetherin and APOBEC3G. Judy Lieberman, Harvard Medical School, presented her group's studies of Trex1, and Jeremy Luban, from the University of Geneva, spoke on TRIM5 Structure and Function in HIV-1 Restriction and Innate Immune Signaling. The day was concluded with two structure-focused talks: Yong Xiong, Yale University, described his crystal structures of Nef in complex with c-terminal domain of MHC-1 and AP-1, and Ellis Reinherz, Harvard Medical School, discussed the gp41 MPER and the development of vaccines against this epitope.

Sixth Annual Meeting of the PCHPI - October 16, 2013

Speakers included Dr. Dmitri Ivanov, from the University of Texas Health Science Center and a recipient of CHEETAH collaboration funds, Dr. Alice Telesnitsky, from the University of Michigan and director of the CRNA, Dr. Greg Towers, University College London, Dr. Volker M. Vogt, Cornell University, and Dr. Masahiro Yamashita, Aaron Diamond AIDS Research Center and recipient of PCHPI collaboration development funds.

Seventh Annual Meeting of the PCHPI - April 15, 2015

The focus of this year's meeting was the application of fluorescent imaging methods to understand HIV-1 infection at a cellular level. The meeting included lectures by international experts on imaging HIV as well as poster presentations by PCHPI members and the broader University of Pittsburgh HIV research community. At least 45 individuals participated in the meeting, including visitors from Case Western University and collaborators from the University of Illinois at Urbana-Champaign. The following individuals presented: Tom Hope gave an overview of his efforts to image HIV-1 PICS and capsid uncoating. He also presented an assay of uncoating and discussed the role of capsid in the early aspects of the retroviral lifecycle. James B. Munro, an Assistant Professor at Tufts University School of Medicine, described his single-molecule imaging studies to understand the conformational dynamics of HIV-1 gp120 and Gag proteins. Sanford Simon presented “Biogenesis of Retroviruses: Lessons from studying the assembly of individual virions of HIV-1”. Marcel Bruchez, a chemist at Carnegie Mellon University, discussed fluorogen activating proteins (FAPs), the dyes that bind them, and novel applications of his fluorescent reagents. Zandrea Ambrose, from our center, discussed her recent efforts to apply live-cell and super resolution microscopy to follow HIV-1 trafficking to the nucleus. At the conclusion of each talk, discussions of approaches and reagents benefited many of the participants.

The eighth annual meeting of the Pittsburgh Center for HIV Protein Interactions (PCHPI) is planned for September 14, 2016. At present, Ian Taylor (The Francis Crick Institute, UK), Heinrich Gottlinger (University of Massachusetts Medical School), Welkin Johnson (Boston College), and Mojgan Naghavi (Northwestern University Feinberg School of Medicine) are slated to present.  An additional speaker will be invited from within our center and/or from the P50 sister centers.

 

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