PCHPI members Zandrea Ambrose and Simon Watkins work closely together to visualize the intracellular dynamics of HIV-1 components during the processes of HIV-1 CA core uncoating, reverse transcription, and PIC nuclear entry, by live-cell and high-resolution fixed cell microscopy, using existing and novel technologies. These investigators use labeled virions and host cell proteins for conducting imaging studies and develop novel techniques to track post-entry events, visualizing viral protein and nucleic acids that interact with host proteins using a complete array of super-resolution, optical sectioning, and wide field approaches.

The imaging technology is primarily housed within theĀ Center for Biologic Imaging (CBI), which is equipped to perform a continuum of optical methods, including all types of microscopy essential to the PCHPI.

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