Methodological and Technical Expertise
The primary rationale for the PCHPI organization is to maximize interdisciplinary collaboration and access to the PCHPI resources, while maintaining focused expertise in technical disciplines. The Center is organized around four methodological cores (Computational, Cryo-EM/ET, NMR, and HIV Virology) and three scientific projects (1. Maturation; 2. Trafficking, Restriction and Nuclear Entry; and 3. Integration). The cores are complemented by the expertise of our collaborators in several important areas. Together, close collaboration among the research groups and cores allows the PCHPI to take a "hybrid" approach to answer important structural, biochemical, and biophysical questions about HIV-1.